A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01)
Patent
CA 2560903
A method of using EMMPRIN antagonists to treat pathological processes associated with proliferative diseases, such as cancer, by specifically preventing or inhibiting the ability of new tissue to develop a blood supply. The invention more specifically relates to methods of treating such diseases by the use of EMMPRIN antagonists such as antibodies directed toward EMMPRIN, including specified portions or variants, specific for at least one EMMPRIN protein or fragment thereof, in an amount effective to inhibit angiogenesis.
Cette invention concerne une méthode d'utilisation d'antagonistes de l'inducteur de métalloprotéinisae dans la matrice extracellulaire (EMMPRIN) pour le traitement de processus pathologiques associés à des maladies prolifératives telles que le cancer, consistant spécifiquement à empêcher ou à inhiber l'aptitude de tissus neufs à produire du sang. Plus spécifiquement, l'invention concerne des méthodes de traitement de telles maladies au moyen d'antagonistes de EMMPRIN tels que des anticorps dirigés contre EMMPRIN, y compris de parties ou de variantes spécifiées, qui sont spécifiques d'au moins une protéine EMMPRIN ou d'un fragment de cette protéine, ceci en quantité suffisante pour inhiber efficacement une angiogenèse.
Nakada Marian
Tang Yi
Yan Li
Centocor Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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