Use of enzyme inhibitors with aminopeptidase n and/or...

Details Use of enzyme inhibitors with aminopeptidase n and/or... Use of enzyme inhibitors with aminopeptidase n and/or...

A - Human Necessities

61

K

A61K 38/05 (2006.01) A61K 31/195 (2006.01) A61K 38/55 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2478760

The invention relates to a method for the inhibition of the DNA synthesis necessary for the proliferation of human sebaceous cells by the single or combined effect of inhibitors of alanylaminopeptidase (APN) and dipeptidylpeptidase IV (DP IV) expressed by said cells. DNA-synthesis (proliferation) of human sebaceous cells is inhibited by the administration of APN or/and DP IV in a dose-dependent manner. The invention is characterised in that the application of inhibitors of the above enzymes or corresponding preparations and dosage forms are suitable for the therapy and prevention of dermatological diseases with seborrhoeic proliferation and altered differentiation states.

L'invention concerne un procédé permettant d'inhiber la réplication de l'ADN de sébocytes humains nécessaire à la prolifération par l'action isolée ou conjointe d'inhibiteurs de l'alanylaminopeptidase (APN) et de la dipeptidylpeptidase IV (DP IV) exprimées par ces cellules. La réplication de l'ADN (prolifération) de sébocytes humains est inhibée selon l'apport d'inhibiteurs de l'APN et/ou de la DP IV. L'invention montre que l'application d'inhibiteurs des enzymes susmentionnés, des préparations correspondantes et de formes de présentation dérivées convient au traitement et à la prévention de maladies dermatologiques avec hyperprolifération de sébocytes et des états de différenciation modifiés.

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