Use of ep4 receptor ligands in the treatment of il-6...

Details Use of ep4 receptor ligands in the treatment of il-6... Use of ep4 receptor ligands in the treatment of il-6...

A - Human Necessities

61

K

A61K 31/635 (2006.01) A61K 31/00 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/4188 (2006.01) A61K 31/42 (2006.01) A61K 31/421 (2006.01) A61K 31/422 (2006.01) A61K 31/426 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61K 31/4745 (2006.01) A61K 31/498 (2006.01) A61K 31/502 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61K 31/53 (2006.01) A61P 1/16 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) A61P 37/06 (2006.01) C12Q 1/02 (200

Patent

CA 2481535

The present invention relates to the use of an EP4 receptor ligand in the manufacture of a medicament for the treatment of IL-6 involved diseases. Also relates to the assay comprising: culturing peripheral whole blood with a test compound; and determining the effect of the compound on PGE2-induced whole blood cells activation.

L'invention concerne l'utilisation d'un ligand du récepteur EP4 dans la fabrication d'un médicament destiné au traitement de maladies impliquant IL-6. L'invention concerne également l'analyse consistant à mettre en culture du sang total périphérique avec un composé d'essai et à déterminer l'effet de ce composé sur l'activation induite par PGE2 des cellules du sang total.

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