Use of estradiol valerate or 17.beta.-estradiol in...

A - Human Necessities – 61 – K

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A61K 31/565 (2006.01) A61K 31/57 (2006.01) A61P 15/00 (2006.01) A61P 15/12 (2006.01) A61P 15/18 (2006.01)

Patent

CA 2666829

The invention relates to the use of estradiol valerate or estradiol in combination with 17a-cyanomethyl-17-.beta.-hydroxyestra-4,9-dien-3-one (dienogest) in a multiphase or single-phase combination preparation for oral therapy for maintaining and/or increasing the female libido, optionally also in unity with oral contraception. The total daily dose units of the multiphase combination and of the pharmaceutically acceptable placebo or of the single-phase combination and the active-ingredient-free and placebo-free daily dose units correspond to 28 days.

L'invention concerne l'utilisation de valérate d'AEstradiol ou d'AEstradiol en combinaison avec de la 17.alpha.-cyanométhyl-17.beta.-hydroxyAEstra-4,9-dién-3-one (Diénogest) dans une préparation mixte multiphasique ou monophasique destinée à la thérapie orale de maintien et/ou d'augmentation de la libido féminine, le cas échéant associée également à une contraception orale. Les unités de doses journalières totales de la combinaison multiphasique et du placebo pharmaceutiquement neutre ou de la combinaison monophasique et des unités de doses journalières sans principe actif et sans placebo correspondent à 28 jours.

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