A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/565 (2006.01) A61K 31/00 (2006.01)
Patent
CA 2254339
The present invention relates to the use of oestrogen or a functional equivalent thereof to modify the amount of SERT or of SERT mRNA in order to combat disorders such as depressive disorders, migraine or irritable bowel syndrome. The invention provides medicaments comprising oestrogen or a functional equivalent to be administered in a pharmaceutical format. The invention also provides a method of selecting agents able to act as anti- depressants based on the ability of the agents to affect or mimic the association of SERT and oestrogen.
Utilisation d'oestrogènes ou d'un équivalent fonctionnel, destinée à modifier la quantité de transporteur de sérotonine ou d'ARNm de transporteur de sérotonine pour lutter contre des troubles tels que la dépression, la migraine ou le syndrome du colon irritable. La présente invention concerne des médicaments contenant des oestrogènes ou un équivalent fonctionnel, à administrer sous forme pharmaceutique. Elle concerne également un procédé de sélection d'agents capables d'agir comme antidépresseurs sur la base de la capacité desdits agents à affecter ou à imiter l'association de transporteur de sérotonine et d'oestrogènes.
Fink George
Mcqueen Judith Katherine
Wilson Helen
Fetherstonhaugh & Co.
Medical Research Council
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