Use of ethanol as plasticizer for preparing subcutaneous...

Details Use of ethanol as plasticizer for preparing subcutaneous... Use of ethanol as plasticizer for preparing subcutaneous...

A - Human Necessities

61

K

A61K 9/22 (2006.01)

Patent

CA 2530117

Using ethanol as plasticizer for preparing subcutaneous implants containing a dispersed active principle in a PLGA-based matrix by means of extrusion, the extrusion temperature, generally higher than 75~C, can be reduced to temperatures higher than the Tg of the PLGA, but lower than the boiling point of ethanol and therefore less than 70~C. In this manner subcutaneous implants containing thermolabile active principles, for example proteins, can be prepared.

L'invention concerne l'utilisation d'éthanol en tant qu'agent plastifiant pour préparer des implants sous-cutanés contenant un principe actif dispersé dans une matrice à base de PLGA, au moyen d'une extrusion. La température d'extrusion, généralement supérieure à 75 ·C, peut être réduite à des températures plus élevées que celle du Tg du PLGA, mais inférieures au point d'ébullition de l'éthanol, et par conséquent inférieures à 70 ·C. De cette manière, des implants sous-cutanés contenant des principes actifs thermolabiles, par exemple des protéines, peuvent être préparés.

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