Use of factor xiiia inhibitors to treat atherosclerosis

A - Human Necessities – 61 – K

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A61K 38/48 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) C12N 9/10 (2006.01) C12N 9/48 (2006.01) C12N 9/68 (2006.01) C12N 9/99 (2006.01)

Patent

CA 2293302

A method of treating a mammal, preferably a human, having atherosclerotic disease is provided. The method comprises administering to the mammal an inhibitor of Factor XIIIa which is involved in the formation of atherosclerotic lesions. Methods for identifying Factor XIIIa inhibitors are also provided.

L'invention concerne un procédé de traitement d'un mammifère, de préférence, un humain, souffrant d'une affection athérosclérotique. Ledit procédé consiste à administrer au mammifère un inhibiteur du Facteur XIIIa impliqué dans la formation de lésions athérosclérotiques. Des procédés d'identification des inhibiteurs du Facteur XIIIa sont également décrits.

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