C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/52 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2189778
Soluble mouse and human Fas ligand polypeptides and methods for inhibitng T-lymphocyte-mediated immune responses, including those directed against autologous and/or heterologous tissues, e g., by a recipient mammal of a transplanted tissue, by providing the recipient mammal with Fas ligand. The Fas ligand may be provided to the recipient mammal by a variety of means,including by direct administration of the Fas ligand or by providing the gene encoding the Fas ligand to a subject such that Fas ligand is synthesized by the subject.
La présente invention concerne des polypeptides solubles du ligand Fas chez l'homme et la souris ainsi que des procédés permettant d'inhiber, notamment chez un mammifère receveur d'un tissu transplanté, les réactions immunitaires liées au lymphocyte T (y compris celles qui sont dirigées contre les tissus autologues et/ou hétérologues), en administrant un ligand Fas au mammifère receveur. Ce ligand Fas est administrable selon différents procédés, y compris par l'administration directe du ligand Fas ou par l'administration, à un sujet, du gène codant le ligand Fas pour que le sujet synthétise le ligand Fas.
Bellgrau Donald
Duke Richard C.
Bellgrau Donald
Duke Richard C.
Smart & Biggar
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