Use of fatty acid esters as bioadhesive substances

Details Use of fatty acid esters as bioadhesive substances Use of fatty acid esters as bioadhesive substances

A - Human Necessities

61

K

A61K 47/14 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 47/24 (2006.01) C09J 11/00 (2006.01)

Patent

CA 2186750

The fatty acid esters have molecular weights below about 1000 dalton and the fatty acid component of the fatty acid ester is a saturated or unsaturated fatty acid having a total number of carbon atoms of from C8 to C22. Particularly suitable fatty acid esters for use according to the invention are fatty acid esters which are selected from the group consisting of fatty acid esters of polyhydric alcohols, fatty acid esters of hydroxycarboxylic acids, fatty acid esters of monosaccharides, fatty acid esters of glycerylphosphate derivatives, fatty acid esters of glycerylsulfate derivative, and mixtures thereof. Excellent bioadhesive properties have been observed for fatty acid esters of glyceryl monooleate, glyceryl monolinoleate or glyceryl monolinolenate. Methods are described for administering an active or protective substance to undamaged or damaged skin or mucosa of an animal such as a human by combining the active or protective substance with a bioadhesive fatty acid ester. The mucosa may be the oral, aural, nasal, lung, gastrointestinal, vaginal, or rectal mucosa. The administration may also be to body cavities such as the oral cavity, e.g. via buccal administration.

On utilise comme substances bioadhérentes des esters d'acides gras d'un poids moléculaire inférieur à 1000 daltons, l'acide gras de ces esters étant saturé ou non et comptant au total 8 à 22 atomes de C. Des esters d'acides gras particulièrement appropriés selon l'invention sont sélectionnés dans le groupe de ceux de polyols, d'acides hydroxycarboxyliques, de mono-saccharides, de dérivés de glycérylphosphates ou glycérylsulfates, et de leurs mélanges. On a constaté d'excellentes propriétés bioadhérentes dans le cas des esters d'acides gras de mono-oléate ou monolinoléate ou monolinolénate de glycéryle. On décrit des procédés qui permettent d'administrer une substance active ou protectrice à la peau ou aux muqueuses, qu'elles aient subi des lésions ou non, d'un sujet, humain par exemple, en la combinant avec un ester d'acide gras bioadhérent. La muqueuse choisie peut être buccale, nasale, gastrointestinale, vaginale, rectale, ou être celle de la gorge et des voies respiratoires. L'administration peut aussi avoir lieu dans des cavités corporelles telle que la cavité buccale, par la voie orale par exemple.

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