Use of flunisolide to treat respiratory diseases

Details Use of flunisolide to treat respiratory diseases Use of flunisolide to treat respiratory diseases

A - Human Necessities

61

K

167/193

A61K 31/56 (2006.01)

Patent

CA 1083963

USE OF FLUNISOLIDE TO TREAT RESPIRATORY DISEASES Abstract of The Disclosure Flunisolide, 6.alpha.-fluoro-11.beta.,21-dihydroxy-16.alpha.,17.alpha.-isopropyli- denedioxypregna-1,4-diene-3,20-dione, is administered by inhala- tion in a therapeutically effective dosage to a person having a respiratory disease such as bronchial asthma and allergic rhinitis. A unique crystalline polymorphic form of flunisolide is prepared by contacting one of the other polymorphic forms o solid flunisolide with a suitable liquid in which flunisolide has substantially no solubility, especially Freon? 12 or Freon? 114 or by recrystallizlng the unique crystalline form from a suitable solvent such as methylene chloride. The unique crystalline form is stable in aerosols such as Freon? mixtures and is valuable in the treatment of respiratory diseases.

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