A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/74 (2006.01) A61K 9/06 (2006.01) A61K 9/10 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61P 11/06 (2006.01) C07K 14/195 (2006.01) C12N 1/20 (2006.01)
Patent
CA 2679686
A pharmaceutical composition for treating or preventing a Th2-mediated disease or disorder includes live, killed or attentuatedFranciscella tularensis or its components. The F. tularensis cells may be LVS cells. Administration of an effective amount may prevent or reduce bronchoconstriction or allergic airway inflammation through a T-helper cell (Th) 1-mediated suppression of an ongoing Th2 response mechanism.
La présente invention concerne une composition pharmaceutique pour traiter et prévenir une maladie ou trouble lié(e) à Th2 comportant une cellule Franciscella tularensis vivant, morte ou atténuée ou ses constituants. Les cellules Franciscella tularensis peuvent être des cellules LVS. L'administration d'une quantité efficace peut prévenir ou réduire la bronchoconstriction ou l'inflammation allergique des voies aériennes grâce à la suppression par l'intermédiaire du lymphocyte T auxiliaire d'un mécanisme de réponse Th2 en cours.
Chen Wangxue
Patel Girishchandra Babubhai
Bennett Jones Llp
National Research Council Of Canada
LandOfFree
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