Use of fredericamycin a and its derivatives in the treatment...

A - Human Necessities – 61 – K

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Details

A61K 31/7048 (2006.01) A61K 31/122 (2006.01) A61K 31/335 (2006.01) A61K 31/37 (2006.01) A61K 31/382 (2006.01) A61K 31/403 (2006.01) A61K 31/47 (2006.01) A61K 31/473 (2006.01) A61K 31/4747 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2432981

This invention provides a method for treating a Pin1-associated state in a subject including administering to a subject an effective amount of a fredericamycin A compound such that the Pin1-associated state is treated. In another aspect, this invention includes the above described method, wherein the Pin1-associated state is a cyclin D1 elevated state, neoplastic transformation, and/or tumor growth. In an embodiment, this invention provides the above described methods, wherein the Pin1-associated state is colon cancer, breast cancer, a sarcoma, a malignant lymphoma, and/or esophageal cancer. This invention also provides a method for treating cyclin D1 overexpression in a subject including administering to a subject an effective amount of a combination of a fredericamycin A compound and a hyperplastic inhibitory agent such that the cyclin D1 overexpression is treated.

L'invention concerne une méthode de traitement d'une pathologie associée à Pin1 chez un sujet, consistant à administrer à ce sujet une quantité efficace d'un composé de frédéricamycine A, de manière à traiter cette pathologie associée à Pin1. Selon un autre aspect de cette invention, la pathologie associée à Pin1 dans la méthode décrite ci-dessus est un niveau élevé de cycline D1, une transformation maligne et/ou une croissance tumorale. Dans un mode de réalisation, la pathologie associée à Pin1 dans les méthodes décrites est un cancer du côlon, un cancer du sein, un sarcome, un lymphome malin et/ou un cancer oesophagien. Cette invention concerne également une méthode de traitement d'une surexpression de la cycline D1 chez un sujet, consistant à administrer à ce sujet une quantité efficace d'une combinaison d'un composé de frédéricamycine A et d'un agent inhibiteur hyperplastique, de manière à traiter cette surexpression de la cycline D1.

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