A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2604007
The use of FRIL family proteins to reduce the production of pro-inflammatory cytokines is disclosed. The FRIL proteins can be used in methods of treatment for inflammatory diseases that are characterized by undesirable levels of pro- inflammatory cytokines, and in the manufacture of medicaments for the treatment of such diseases. The inflammatory diseases that can be treated by FRIL proteins include, without limitation, autoimmune disorders, neurodegenerative diseases, and cancers. In addition, the FRIL proteins of the invention can be used as an adjunct therapy to increase tolerance in patients undergoing transplantation.
L'invention concerne l'utilisation de protéines de la famille FRIL (ligand en interaction avec le récepteur de FTL3), les protéines FRIL peuvent s'utiliser dans des méthodes de traitement de maladies inflammatoires, qui sont caractérisées par des taux indésirables de cytokines pro-inflammatoires, ainsi que dans la fabrication de médicaments utilisés dans le traitement de telles maladies. Les maladies inflammatoires pouvant être traitées par les protéines FRIL comprennent, sans limitation: les troubles auto-immuns, les maladies neurodégénératives et les cancers. Les protéines FRIL de l'invention peuvent en outre s'utiliser comme thérapie complémentaire pour augmenter la tolérance chez des patients faisant l'objet de transplantations.
Dinarello Charles A.
Moore Jeffrey G.
Morningside Venture Investments Limited
Smart & Biggar
LandOfFree
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