Use of fxr, ppar.alpha. and lxr.alpha. activators to restore...

A - Human Necessities – 61 – K

Patent

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A61K 31/56 (2006.01) A61K 31/00 (2006.01) A61K 31/045 (2006.01) A61K 31/08 (2006.01) A61K 31/11 (2006.01) A61K 31/192 (2006.01) A61K 31/20 (2006.01) A61K 31/201 (2006.01) A61K 31/202 (2006.01) A61K 31/215 (2006.01) A61K 31/216 (2006.01) A61K 31/22 (2006.01) A61K 31/335 (2006.01) A61K 31/336 (2006.01) A61K 31/45 (2006.01) A61K 31/505 (2006.01) A61K 31/575 (2006.01)

Patent

CA 2278123

Disorders of the skin and mucous membranes that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of compounds that are either activators of the farnesoid X receptor, activators of the peroxisome proliferator-activated receptor .alpha., and oxysterol activators of the LXR.alpha. receptor. The same compounds are also effective in treating disorders of epidermal differentiation and proliferation.

La présente invention permet de prévenir ou de traiter les maladies de la peau et des muqueuses qui présentent une rupture ou un dysfonctionnement de la barrière épidermique par l'application locale de composés constitués d'activateurs du récepteur activé par les farnésoïdes X, d'activateurs du récepteur .alpha. activé par un proliférateur de peroxysomes, et d'activateurs oxystérols du récepteur LXR.alpha.. Les mêmes composés sont également efficaces dans le traitement des troubles de la différenciation et de la prolifération épidermiques.

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