A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/14 (2006.01) A61K 31/235 (2006.01) A61K 31/275 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61K 38/13 (2006.01)
Patent
CA 2364063
A method for increasing bioavailability of an orally administered pharmaceutical compound comprises orally coadministering the pharmaceutical compound to a mammal in need of treatment with the compound and a gallic acid ester. Preferred gallic acid esters of the invention include octyl gallate, propyl gallate, lauryl gallate, and methyl gallate. Improved formulations of pharmaceutical compounds include the gallic acid ester to enhance the biovailability of the active ingredient of the pharmaceutical compound.
L'invention concerne une technique permettant d'augmenter la biodisponibilité d'un composé pharmaceutique administré oralement, qui consiste à co-administrer ledit composé à un mammifère qui a besoin d'être traité avec un ester d'acide gallique. Les esters d'acide gallique préférés comprennent le gallate d'octyle, le gallate de propyle, le gallate de lauryle, et le gallate de méthyle. Des formulations améliorées de ces composés pharmaceutiques comprennent l'ester d'acide gallique qui permet d'améliorer la biodisponibilité de l'ingrédient actif desdits composés pharmaceutiques.
Benet Leslie Z.
Wacher Vincent J.
Avmax Inc.
Fetherstonhaugh & Co.
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