A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/16 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01)
Patent
CA 2290742
The present invention includes methods for treatment and prophylaxis of diseases, post-surgical disorders and bacterial infections associated with lactosylceramide. The methods generally provide for administration for a mammal, particularly a human, of a therapeutically effective amount of a compound that inhibits UDPGal:GlcCer.beta.1-4 galactosylceramide (GalT-2). In vitro and in vivo assays for detecting compounds with therapeutic capacity to modulate GalT-2 are also provided.
La présente invention concerne des procédés de traitement et de prophylaxie de maladies, de troubles post-chirurgicaux et d'infections bactériennes associés au lactosylcéramide. Ces procédés consistent généralement à administrer à un mammifère, en particulier à un être humain, une quantité efficace, dans la perspective thérapeutique, d'un composé qui inhibe le UDPGal:GlcCer.beta.1-?4galactosylcéramide (GalT-2). L'invention concerne également des dosages biologiques in vitro et in vivo permettant de détecter des composés qui, du point de vue thérapeutique, sont susceptibles de moduler le GalT2.
Johns Hopkins University
Ridout & Maybee Llp
LandOfFree
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