Use of gene expression profiling to predict survival in...

Details Use of gene expression profiling to predict survival in... Use of gene expression profiling to predict survival in...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2611696

Gene expression profiling in multiple myeloma patients identifies genes that distinguish between patients with subsequent early death or long survival after treatment. Poor survival is linked to over-expression of genes such as ASPM, 0PN3 andCKSlB which are located in chromosome Iq. Given the frequent amplification of Iq in many cancers, it is possible that these genes can be used as powerful prognostic markers and therapeutic targets for multiple myeloma and other cancer.

Le profilage de l'expression génique chez des patients atteints de myélome multiple permet d'identifier des gènes qui permettent de distinguer entre des patients à mort subséquente rapide et des patients à longue survie après traitement. Une faible survie est liée à une surexpression de gènes tels que ASPM, 0PN3 et CKSlB localisés dans le chromosome Iq. Vu l'amplification fréquente de Iq dans de nombreux cancers, il est possible d'utiliser ces gènes comme marqueurs de pronostic puissants et comme cibles thérapeutiques pour le myélome multiple et d'autres cancers.

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