Use of genetic polymorphisms to predict drug-induced...

Details Use of genetic polymorphisms to predict drug-induced... Use of genetic polymorphisms to predict drug-induced...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2540760

ILIA or a gene located near ILIA on chromosome 2q14 may contribute to hepatotoxicity, as measured by increased serum levels of aspartate transaminase, during N-benzoyl-staurosporine treatment for macular edema. Accordingly, genetic polymorphisms in the ILIA gene are useful as biomarkers for predicting staurosporine derivative-mediated hepatotoxicity.

L'invention concerne <I>IL1A</I> ou un gène situé à proximité sur le chromosome 2q14 pouvant contribuer à l'hépatotoxicité, mesurée à l'augmentation des niveaux sériques d'aspartate transaminase, durant le traitement par N-benzoyle-staurosporine pour l'oedème maculaire. Ainsi, les polymorphismes génétiques dans le gène IL1A peuvent être utiles comme biomarqueurs liés à la prédiction de l'hépatotoxicité dont la médiation est assurée par un dérivé de staurosporine.

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