Use of genetically detoxified pertussis toxin as an adjuvant

Details Use of genetically detoxified pertussis toxin as an adjuvant Use of genetically detoxified pertussis toxin as an adjuvant

A - Human Necessities

61

K

A61K 39/39 (2006.01) A61K 39/10 (2006.01) A61K 39/116 (2006.01)

Patent

CA 2192454

A modulated immune response to an antigen is achieved by coadministering the antigen and a genetically-detoxified pertussis holotoxin, particularly one retaining its immunogenicity, to a host. The modulated immune response enables immunogenic compositions, including multivalent pediatric vaccines such as DTP, to be provided which produce a modulated immune response in the absence of extrinsic adjuvants such as alum. The adjuvanting effect achieved by the genetically-detoxified pertussis holotoxin enables at least the same level of adjuvanting effect to be achieved as previously attained by alum, without the undesirable side effects thereof.

On obtient une réponse immune modulée à un antigène en coadministrant à un hôte ledit antigène et une holotoxine coquelucheuse génétiquement détoxiquée, en particulier une conservant son immunogénicité. La réponse immune modulée permet d'obtenir des composition immunogènes telles que des vaccins pédiatriques plurivalents tels que l'holotoxine coquelucheuse génétiquement détoxiquée (DTP), qui produisent une réponse immune modulée en l'absence d'adjuvants extrinsèques tels que l'alun. L'effet adjuvant produit par l'holotoxine coquelucheuse génétiquement détoxiquée permet d'obtenir le même niveau d'effet adjuvant qu'avec l'alun, sans les effets indésirables de ce dernier.

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