A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/195 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61K 31/565 (2006.01) A61K 31/57 (2006.01) A61P 15/02 (2006.01) A61P 15/12 (2006.01) A61P 15/18 (2006.01) A61P 19/10 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2696030
Antiandrogenic gestagens in a daily dose unit which corresponds to a maximum of twice the ovulation-inhibiting dose are used in combination with (6S)-5-methyltetrahydrofolate for the preparation of pharmaceutical preparations for therapy of endometriosis with simultaneous reduction of therapy side effects, such as the negative influence on bone density/bone metabolism and the risk of osteoporosis, and, at the onset of a pregnancy, reduction of the risk of congenital abnormalities, such as neural canal defects, cleft lip, jaw and palate, and pregnancy complications, such as abruptio placentae and premature birth.
L'invention concerne des gestagènes anti-androgènes en unité posologique quotidienne correspondant au maximum au double de la dose inhibant l'ovulation qui sont utilisés en combinaison avec du (6S)-5-méthyltétrahydrofolate pour la production de préparations pharmaceutiques servant au traitement de l'endométriose avec réduction simultanée d'effets secondaires du traitement, tels que l'influence négative sur la densité osseuse/le métabolisme osseux et le risque d'ostéoporose, ainsi qu'avec diminution du risque de malformations congénitales en début de grossesse, telles que les anomalies du tube neural et les fentes labio-maxillo-palatines, et de complications de grossesse, telles que le décollement du placenta et la prématurité. L'invention convient à une utilisation de longue durée.
Diefenbach Konstanze
King Kristina
Seitz Christian
Wasserfall Annemarie
Zimmermann Holger
Bayer Schering Pharma Aktiengesellschaft
Marks & Clerk
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