Use of glycerophospholipids for joint lubrication

Details Use of glycerophospholipids for joint lubrication Use of glycerophospholipids for joint lubrication

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/685 (2006.01)

Patent

CA 2664944

The present invention concerns the use of liposomes having membranes with at least one phospholipid (PL) of the group consisting of a glycerophospholipid (GPL) having two, being the same or different, C12-C16 hydrocarbon chain and a sphingolipid (SPL) having a C12-C18 hydrocarbon chain, the one or more membranes having a phase transition temperature in which solid ordered (SO) to liquid disordered (LD) phase transition occurs, the phase transition temperature being within a temperature of about 20°C to about 39°C for lubrication of joints.

La présente invention concerne l'utilisation de liposomes qui présentent des membranes pourvues d'au moins un phospholipide (PL) du groupe constitué d'un glycéro-phospholipide (GPL) comportant deux chaînes hydrocarbonées en C12 à C16, identiques ou différentes, et d'un sphingolipide (SPL) comportant une chaîne hydrocarbonée en C12 à C18. Une ou plusieurs des membranes présentent une température de transition de phase au cours de laquelle se produit une transition de phase ordonnée solide (SO) à désordonnée liquide (LD) et la température de transition de phase se situe dans une plage de température allant d'environ 20 °C à environ 39 °C en vue d'une lubrification des articulations.

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