A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 39/015 (2006.01) A61K 39/21 (2006.01) A61P 31/18 (2006.01) A61P 33/06 (2006.01) C07K 14/16 (2006.01) C07K 14/445 (2006.01)
Patent
CA 2453880
The present invention relates to methods and compositions for augmenting an immunogenicity of an antigen in a mammal, comprising administering said antigen together with an adjuvant composition that includes glycosylceramide, preferably .alpha.-galactosylceramide (.alpha.-GalCer). According to the present invention, the use of glycosylceramide as an adjuvant is attributed at least in part to the enhancement and/or extension of antigen-specific Th1-type responses, in particular, CD8+ T cell responses. The methods and compositions of the present invention can be useful for prophylaxis and treatment of various infectious and neoplastic diseases.
La présente invention concerne des méthodes et des compositions destinées à augmenter l'immunogénicité d'un antigène chez un mammifère. Ces méthodes consistent à administrer ledit antigène conjointement avec une composition adjuvante comprenant du glycosylcéramide, de préférence un .alpha.-galactosylcéramide (.alpha.-GalCer). Selon la présente invention, l'utilisation de glycosylcéramide comme adjuvant est attribuée au moins en partie à l'augmentation et/ou à l'extension des réponses de type Th1 spécifiques d'un antigène, et notamment des réponses des lymphocytes T8. Les méthodes et compositions de la présente invention peuvent être utiles pour la prévention et le traitement de diverses infections et maladies néoplasiques.
Gonzalez-Aseguinolaza Gloria
Koezuka Yashuhiko
Tsuji Moriya
Kirin Brewery Company Limited
New York University
Smart & Biggar
LandOfFree
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