Use of growth hormone in low dose

Details Use of growth hormone in low dose Use of growth hormone in low dose

A - Human Necessities

61

K

A61K 38/27 (2006.01) A61P 3/10 (2006.01) A61K 38/12 (2006.01)

Patent

CA 2402948

The invention relates to treatment of patients in need of increasing insulin sensitivity by administration of growth hormone or analogues thereof, preferably human growth hormone, in a low dose and the use of growth hormone or analogues thereof, preferably human growth hormone, for the manufacturing of a medicament useful for increasing insulin sensitivity in low dose therapy. The patient is preferably a normal subject, i.e. not growth hormone deficient patient and/or a non-obese patient. By low dose therapy is preferably meant less than 0.008 mg/kg/day, preferably 0.007 mg/kg/day or less, more preferably 0.005 mg/kg/day or less and most preferably 0.003 mg/kg/day or less. The therapy is preferably performed during short term treatment, preferably less than one month.

L'invention concerne le traitement de patients ayant besoin d'une sensibilité accrue à l'insuline par l'administration de l'hormone de croissance ou de ses analogues, de préférence de l'hormone de croissance humaine, à faible dose. L'invention concerne l'utilisation de l'hormone de croissance ou de ses analogues, de préférence de l'hormone de croissance humaine, pour produire un médicament permettant d'augmenter la sensibilité à l'insuline dans un traitement à faible dose. Le patient est, de préférence, un sujet normal, c'est-à-dire un patient n'ayant pas de déficience d'hormone de croissance et/ou non obèse. On entend par traitement à faible dose, de préférence, moins de 0.008 mg/kg/jour, notamment 0.007 mg/kg/jour maximum, plus particulièrement 0.005 mg/kg/jour maximum ou encore 0.003 mg/kg/jour maximum. Ce traitement est, de préférence, administré pendant une courte durée, de préférence moins d'un mois.

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