A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/4436 (2006.01) A61P 21/00 (2006.01) G01N 33/15 (2006.01)
Patent
CA 2713376
The invention provides methods for the diagnosis and treatment of musculoskeletal disorders relating to the Hedge-hog pathway, including but not limited to muscular dystrophy (e.g., Duchenne Muscular Dystrophy) using agents that agonize Sonic Hedgehog (shh), and thereby, the Hedgehog signaling pathway. Said agonizing agents include, e.g., the compounds of the inven-tion (e.g., a compound of Formula I). The invention also provides methods of screening for agents that are capable of increases the proliferation of muscle and/or muscle precursor cells.
L'invention porte sur des procédés pour le diagnostic et le traitement de troubles musculosquelettiques se rapportant à la voie Hedgehog, comprenant, mais sans y être limités, la dystrophie musculaire (par exemple, la dystrophie musculaire de Duchenne) à l'aide d'agents qui sont des agonistes de Sonic Hedgehog (shh), et par conséquent de la voie de signalisation Hedgehog. Lesdits agents ayant une action d'agoniste comprennent, par exemple, les composés de l'invention (par exemple, un composé de Formule I). L'invention porte également sur des procédés de criblage d'agents qui sont capables d'augmenter la prolifération des cellules de muscle et/ou des cellules précurseurs de muscle.
Armstrong Dustin Donald
Kadam Shilpa
Fetherstonhaugh & Co.
Novartis Ag
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