Use of heparinoid derivatives for treating and diagnosing...

Details Use of heparinoid derivatives for treating and diagnosing... Use of heparinoid derivatives for treating and diagnosing...

C - Chemistry, Metallurgy

08

B

C08B 37/10 (2006.01) A61P 7/02 (2006.01) A61P 19/02 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2457846

The invention relates to heparinoid derivatives, containing a chelating agent that is covalently bound to the heparinoid and a paramagnetic metal cation from the series of transition metals Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Mo, Ru or lanthanides. Said derivatives are suitable for producing medicaments for therapeutic and also diagnostic purposes, for localising the administered dose and for monitoring the treatment success of diseases such as thrombosis and osteo-arthrosis.

La présente invention concerne des dérivés d'héparinoïdes qui comprennent un chélateur, lié par liaison covalente à l'héparinoïde, et un cation métallique paramagnétique, provenant de la série de métaux de transition Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Mo, Ru ou des lanthanides. Ces composés conviennent à la production de médicaments et à une utilisation dans le cadre de la thérapie et du diagnostic et ils permettent la localisation des doses administrées et le contrôle de la réussite du traitement de maladies telles que la thrombose et l'arthrose.

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