Use of histamine h4 receptor modulators for the treatment of...

A - Human Necessities – 61 – K

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Details

A61K 39/00 (2006.01) A61K 47/00 (2006.01) C07K 16/00 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2497788

Methods are disclosed for identifying histamine receptor modulators that affect mast cell or basophil chemotaxis, and the use of such histamine H4 receptor modulators for the prevention, treatment, induction, or other desired modulation of asthma and/or allergic responses, or diseases and/or conditions that are modulated, affected or caused by asthma or allergic responses. Also disclosed is the use of histamine H4 receptor modulators for the prevention, treatment, induction, or other desired modulation of mast cell or basophil chemotactic responses, such as migration to a particular site, or diseases and/or conditions that are modulated, affected or caused by mast cell or basophil chemotaxis.

Procédés permettant d'identifier des modulateurs du récepteur de l'histamine qui influencent la chimiotaxie des mastocytes ou des basophiles, et utilisation de ces modulateurs du récepteur H4 de l'histamine pour la prévention, le traitement, l'induction ou toute autre modulation désirée de l'asthme et / ou des réponses allergiques, ou de maladies et / ou états pathologiques qui sont modulés, influencés ou causés par l'asthme ou des réponses allergiques. La présente invention concerne également l'utilisation des modulateurs du récepteur H4 de l'histamine pour prévenir, traiter, induire ou moduler de toute autre manière désirée les réponses chimiotaxiques des mastocytes ou des basophiles, telles que la migration vers un site particulier, ou des maladies et / ou des états pathologiques qui sont modulés, influencés ou causés par la chimiotaxie des mastocytes ou des basophiles.

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