Use of hmg fragment as anti-inflammatory agents

Details Use of hmg fragment as anti-inflammatory agents Use of hmg fragment as anti-inflammatory agents

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C12N 15/12 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2447576

Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMG A box, and an antibody preparation that specifically binds to a vertebrate HMG B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.

La présente invention concerne des compositions et des méthodes qui permettent d'inhiber la libération d'une cytokine pro-inflammatoire provenant d'une cellule de vertébré et d'inhiber une cascade de cytokines inflammatoires chez un patient. Les compositions comprennent une boîte HMG A de vertébré et une préparation d'anticorps qui se lie de manière spécifique à une boîte HMG B de vertébré. Les méthodes consistent à traiter une cellule ou un patient avec des quantités suffisantes de la composition pour inhiber la libération de la cytokine pro-inflammatoire ou pour inhiber la cascade de cytokines inflammatoires.

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