A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/19 (2006.01) A61P 17/02 (2006.01)
Patent
CA 2574548
The present invention describes the role of HMGB1 in improving wound healing, in particular in a model of diabetes. Other evidences based on the effect of glycyrrhizin, the underexpression of HMGB1 in the skin and fibroblast of diabetic subjects, the accumulation of RAGE in the skin of diabetic mice and the chemoattractant properties of HMGB1 on normal and diabetic human cells demonstrate that HMGB1 can be advantageously utilized for preparing medicament specifically devoted to wound healing, in particular for diabetic subjects.
La présente invention traite du rôle de HMGB1 dans l'amélioration de la cicatrisation des plaies, en particulier dans un modèle de diabète. D'autres éléments concernant les effets de la glycyrrhizine, la sous-expression de HMGB1 dans la peau et le fibroblaste de patients diabétiques, l'accumulation de RAGE dans la peau de souris diabétiques, et les propriétés de chimio-attraction de HMGB1 sur des cellules humaines normales et diabétiques montrent que HMGB1 peut être utilisée avantageusement dans la préparation d'un médicament spécialement conçu pour la cicatrisation des plaies, en particulier chez des patients diabétiques.
Bianchi Marco
Colognesi Capogrossi Maurizio
Germani Antonia
Centro Cardiologico Monzino S.p.a.-Irccs
Dennison Associates
Fondazione Centro San Raffaele Del Monte Tabor
Provincia Italiana Della Congregazione Dei Figli Dell'immacolata
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