A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 31/7105 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 9/10 (2006.01) A61P 29/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2491321
It is described a composition comprising an effective amount of the HMGB1 protein or functional parts thereof, or HMGB1 expressing vectors, for the treatment of tissue damage and/or to promote tissue repair and regeneration. It is further described a composition comprising an effective amount of an antagonist of the HMGB1 protein for the treatment of adverse effects induced by necrotic tissue, such as recruitment and activation of myeloid cells, loss of the barrier function of endothelia, edema.
La présente invention concerne une composition qui comprend une quantité efficace de la protéine HMGB1 ou de parties fonctionnelles de cette dernière, ou des vecteurs exprimant HMGB1, qu'on utilise pour le traitement des lésions tissulaires et/ou pour activer la réparation et la régénération tissulaires. Cette invention concerne également une composition qui comprend une quantité efficace d'un antagoniste de la protéine HMGB1 qu'on utilise pour le traitement de divers effets indésirables induits par les tissus nécrotiques, tels que le recrutement et l'activation des cellules myéloïdes, la perte de la fonction barrière de l'endothélium, l'oedème.
Bianchi Marco Emilio
Colognesi Capogrossi Maurizio
Germani Antonia
Limana Federica
Palumbo Roberta
Centro Cardiologico Monzino S.p.a.-Irccs
Dennison Associates
Fondazione Centro San Raffaele Del Monte Tabor
Provincia Italiana Della Congregazione Figli Dell'immacolata Con
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