Use of hyaluronidase

Details Use of hyaluronidase Use of hyaluronidase

A - Human Necessities

61

K

A61K 38/47 (2006.01)

Patent

CA 2262637

The use of hyaluronidase in the manufacturing of a drug for the treatment of conditions of interstitial edema in connection with organ grafting associated with an increased local content of hyaluronan in the connective tissue of a mammal. The drug comprises hyaluronidase in an amount giving a daily dosage of from 1 to 100,000 IU/kg body weight when given locally or systemically to a mammal. A method of treating conditions of interstitial edema in connection with organ grafting associated with an increased local synthesis of hyaluronan by systemic or local treatment with a pharmaceutical comprising hyaluronidase.

Utilisation de hyaluronidase dans la préparation d'un médicament servant à traiter un état d'oedème interstitiel provenant d'une greffe d'organe associée à une augmentation de la teneur locale en hyaluronane dans le tissu conjonctif d'un mammifère. Ce médicament contient hyaluronidase selon une quantité permettant un dosage journalier de 1 à 100 000 IU/kg de poids du corps quand on l'administre au mammifère de façon locale ou systémique. Procédé servant à traiter des états d'oedème interstitiel provenant d'une greffe d'organe associée à une augmentation de la synthèse locale de hyaluronane au moyen d'un traitement local ou systémique au moyen d'un médicament pharmaceutique contenant hyaluronidase.

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