Use of hyaluronidase in the manufacture of an ophthalmic...

A - Human Necessities – 61 – K

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A61K 38/47 (2006.01)

Patent

CA 2288622

An enzymatic method is provided for treating ophthalmic disorders of the mammalian eye. Prevention of neovascularization and the increased rate of clearance from the vitreous of materials toxic to retina is accomplished by administering an amount of hyaluronidase effective to liquefy the vitreous humor of the treated eye without causing toxic damage to the eye. Liquefaction of the vitreous humor increases the rate of liquid exchange from the vitreal chamber. This increase in exchange removes those materials and conditions whose presence causes ophthalmological and retinal damage.

Cette invention concerne un procédé enzymatique qui permet de traiter des troubles ophtalmiques de l'oeil d'un mammifère. Pour prévenir la néovascularisation et augmenter la vitesse d'élimination de matières toxiques pour la rétine présentes dans le corps vitré, on administre une quantité efficace d'hyaluronidase pour fluidifier l'humeur vitreuse de l'oeil traité sans provoquer de dommage toxique chez ce dernier. La fluidification de l'humeur vitreuse augmente la vitesse de l'échange de liquide dans l'espace compris entre la rétine et la face postérieure du cristallin. Cet accroissement de l'échange permet d'éliminer les matières et les conditions dont la présence provoque des dommages ophtalmiques et rétiniens.

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