Use of hydrophobic crosslinking agents to prepare...

Details Use of hydrophobic crosslinking agents to prepare... Use of hydrophobic crosslinking agents to prepare...

C - Chemistry, Metallurgy

08

H

C08H 1/00 (2006.01) A61L 24/08 (2006.01) A61L 26/00 (2006.01) A61L 27/00 (2006.01) A61L 27/20 (2006.01) A61L 27/24 (2006.01) A61L 31/04 (2006.01) C08B 37/00 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2165728

The present invention discloses novel crosslinked biomaterial compositions which are prepared using hydrophobic polymers as a crosslinking agent. Preferred hydrophobic polymers are those that contain two or more reactive succinimidyl groups, including disuccinimidyl suberate, bis(sulfosuccinimidyl) suberate, and dithiobis(succinimidylpropionate). Crosslinked biomaterial compositions prepared using mixtures of hydrophobic and hydrophilic crosslinking agents are also disclosed. The compositions of the present invention can be used to prepare formed implants for use in a variety of medical applications.

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