C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/226, 260/277
C07D 401/04 (2006.01) A61K 31/47 (2006.01)
Patent
CA 1312082
Abstract A method for the treatment and/or prophylaxis of cerebrovascular disorders and/or disorders associated with cerebral senility in mammals, such as humans, which comprises administering to the mammal in need of such treatment and/or prophylaxis an effective and/or prophylactic amount of a compound of formula (I): Image (I) wherein: n is 1 or 2; R1 is chloro, bromo, C1-6alkylcarbonyl or cyano; one of R3 and R4 is hydrogen or C1-4 alkyl and the other is C1-4 alkyl or R3 and R4 together are C2-5 polymethylene; and either R5 is hydroxy, C1-3 alkoxy or C1-8 acyloxy; and R2 is hydrogen and the cyclic amide moiety and R5 are trans; or R5 and R2 together form a bond, novel compounds within formula (I), processes for their preparation.
514877
Angersbach Dieter
Evans John Morris
Nicholson Charles David
Stemp Geoffrey
Beecham Group P.l.c.
Beecham-Wuelfing G.m.b.h. & Co Kg
Borden Ladner Gervais Llp
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