Use of hydroxy tetrahydro-naphtalene derivates for the...

A - Human Necessities – 61 – K

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A61K 31/17 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2599778

This invention relates to new uses of hydroxy-tetrahydro-naphthalenylurea derivatives which are described in WO 03/095420 as an active ingredient of pharmaceutical preparations for the treatment of diseases associated with VR1 activity. The new uses of the present invention are the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of respiratory diseases or disorders such as the common cold, cough, sneeze, bronchitis including acute and chronic bronchitis, bronchiolitis, rhinitis, allergic rhinitis, vasomotor rhinitis, mucositis, sinusitis, allergy, disorders associated with exogenous irritants such as tobacco smoke, smog, high levels of atmospheric SO2 and noxious gases in the workplace, and airways hyperreactivity, milk product intolerance, Loffler's pneumonia, emphysema, cystic fibrosis, bronchiectasis, pulmonary fibrosis, pneumoconiosis, collagen vascular disease, granulomatous disease, laryngitis, pharyngitis, pneumonia, pleuritis, persistent asthma and chronic asthmatic bronchitis.

L'invention concerne de nouvelles utilisations de dérivés d'hydroxy-tétrahydro-naphthalénylurée qui sont décrites dans WO 03/095420 en tant que principes actifs de préparations pharmaceutiques pour le traitement de maladies associées à l'activité VR1. Ces nouvelles utilisations de la présente invention sont la prophylaxie et le traitement de maladies associées à l'activité VR1, notamment le traitement de maladies ou de troubles respiratoires tels que le rhume simple, la toux, l'éternuement, la bronchite y compris la bronchite aiguë et chronique, la bronchiolite, la rhinite, la rhinite allergique, la rhinite vasomotrice, la mucosité, la sinusite, l'allergie, les troubles associés à des irritants exogènes tels que la fumée, le brouillard de fumée, de hauts niveaux de gaz toxiques et de SO2 atmosphérique sur le lieu de travail, et l'hyperactivité des voies aériennes, l'intolérance aux produits laitiers, le syndrome de Loffler, l'emphysème, la mucoviscidose, la bronchectasie, la fibrose pulmonaire, la pneumoconiose, la collagénose avec manifestations vasculaires, la maladie granulomateuse, la laryngite, la pharyngite, la pneumonie, la pleurésie, l'asthme persistant et la bronchite asthmatique chronique.

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