Use of i) a polyglycol and ii) an active drug substance for...

A - Human Necessities – 61 – K

Patent

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A61K 9/22 (2006.01) A61K 31/485 (2006.01)

Patent

CA 2674536

Abuse resistant polyglycol-based pharmaceutical compositions are disclosed. The composition contains one or more polyglycols and one or more active substances and it is resistant to crushing, melting and/or extraction. Moreover, such compositions have the same or lower solubility in ethanolic-aqueous medium, i.e. they are not subject to ethanol-induced dose dumping effect.

L'invention concerne des compositions pharmaceutiques à base de polyglycol qui offrent une résistance à la toxicomanie médicamenteuse. La composition selon l'invention contient au moins un polyglycol et au moins une substance active et elle résiste au broyage, à la fusion et/ou à l'extraction. Les compositions précitées possèdent en outre une solubilité en milieu éthanolique qui est équivalente ou inférieure à leur solubilité en milieu aqueux, c'est-à-dire qu'elles ne sont pas sujettes à une libération massive induite par l'éthanol.

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