Use of il-12 and il-12 antagonists in the treatment of...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61P 37/02 (2006.01) A61K 38/20 (2006.01)

Patent

CA 2185565

Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL.12 or an IL,12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-.gamma. or TNF-.alpha.. Suitable conditions for treatment include multiple sclerosis systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes melitis and autoimmune inflammatory eye disease.

La présente invention concerne des états justifiant le traitement de maladies auto-immunes par l'administration d'IL-12 ou d'un antagoniste d'IL-12 à un sujet mammifère. Dans certaines réalisations préférées, l'état d'auto-immunité est l'un de ceux qui sont favorisés par l'accroissement des taux d'IFN-.gamma. ou de TNF-.alpha.. Les états justifiant le traitement sont notamment la sclérose en plaques, le lupus érythémateux aigu disséminé, la polyarthrite rhumatoïde, l'inflammation pulmonaire auto-immune, le syndrome de Guillain-Barré, la thyroïdite auto-immune, le diabète sucré insulinodépendant, et l'inflammation chronique auto-immune de l'oeil.

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