Use of il-13 receptor subunit alpha 2 as an anti-cancer vaccine

Details Use of il-13 receptor subunit alpha 2 as an anti-cancer vaccine Use of il-13 receptor subunit alpha 2 as an anti-cancer vaccine

A - Human Necessities

61

K

A61K 38/00 (2006.01) A01K 43/04 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) C07K 1/00 (2006.01) C07K 2/00 (2006.01) C07K 4/00 (2006.01) C07K 7/00 (2006.01) C07K 14/00 (2006.01) C07K 14/715 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2480008

A method for stimulating an immune response against IL-12R.alpha.2 in a subject having or at risk for developing a disease having cells expressing IL- 13R.alpha.2 includes the steps of formulating the anti-cancer vaccine outside of the subject and administering the vaccine to the subject in an amount sufficient to stimulate an immune response against IL-13R.alpha.2 in the subject. A composition for stimulating an immune response agaist IL- 13R.alpha.2 in a subject having or at risk for developing a disease having cells expressing IL-13R.alpha.2 includes an isolated agent that can stimulate immune response against IL-13.alpha.2.

L'invention concerne une méthode destinée à stimuler une réponse immunitaire contre IL-13R.alpha.2 chez un sujet atteint ou risquant d'être atteint d'une maladie dans laquelle des cellules expriment IL-13R.alpha.2. Cette méthode consiste à formuler un vaccin anti-cancer à l'extérieur du sujet et à administrer ce vaccin au sujet dans une quantité suffisante pour stimuler une réponse immunitaire contre IL-13R.alpha.2 chez ledit sujet. L'invention concerne en outre une composition pour stimuler une réponse immunitaire contre IL-13R.alpha.2 chez un sujet atteint ou risquant d'être atteint d'une maladie dans laquelle des cellules expriment IL-13R.alpha.2, cette composition comprenant un agent isolé pouvant stimuler une réponse immunitaire contre IL-13R.alpha.2.

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