Use of il-28 and il-29 to treat cancer and autoimmune disorders

Details Use of il-28 and il-29 to treat cancer and autoimmune disorders Use of il-28 and il-29 to treat cancer and autoimmune disorders

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61P 35/00 (2006.01) C07K 14/54 (2006.01)

Patent

CA 2574564

Methods for treating patients with cancer and autoimmune disorders using IL-28 and IL-29 molecules. The IL-28 and IL-29 molecules include polypeptides that have homology to the human IL-28 or IL-29 polypeptide sequence and proteins fused to a polypeptide with IL-28 and IL-29 functional activity. The molecules can be used as a monotherapy or in combination with other known cancer and/or autoimmune therapeutics.

L'invention concerne des procédés de traitement de patients atteints de cancer et de troubles autoimmuns au moyen des molécules IL-28 et IL-29. Les molécules IL-28 et IL-29 contiennent des polypeptides qui présentent une homologie avec les séquences polypeptidiques IL-28 ou IL-29 et les protéines fondues sur un polypeptide à activité fonctionnelle de IL-28 et IL-29. Ces molécules peuvent être utilisées en monothérapie ou en polythérapie lorsqu'elles sont associées à d'autres thérapies contre le cancer et/ou les troubles autoimmuns.

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