A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/445 (2006.01) A61K 31/40 (2006.01) A61P 31/14 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2500940
Disclosed are methods and kits to treat HCV infection by administering an iminosugar derivative compound that is effective to inhibit the activity of HCV p7 protein, and methods by which to screen for compounds that inhibit the activity of p7 protein or variants thereof. The disclosed N-substituted imino compounds, and pharmaceutical compositions thereof, inhibit the capability of HCV p7 to permeabilize membranes. Particularly efficacious compounds are imino sugars derived from N-alkylated piperidines. Also disclosed are methods for screening for potential HCV antiviral agents.
Méthodes et kits permettant de traiter l'infection due au virus de l'hépatite C (VHC) par administration d'un composé dérivé d'iminosucre capable d'inhiber l'activité de la protéine p7 de VHC, et méthodes permettant de cribler des composés qui inhibent l'activité de la protéine p7 ou des variantes de ladite protéine. Les composés imino à substitution N selon la présente invention et les compositions pharmaceutiques les contenant inhibent la capacité de p7 de VHC de perméabiliser les membranes. Les iminosucres dérivés de pipéridines N-alkylées sont des composés particulièrement efficaces. La présente invention concerne également des méthodes de criblage d'agents antiviraux potentiels contre le VHC.
Dwek Raymond
Zitzmann Nicole
Mccarthy Tetrault Llp
The Chancellor Masters And Scholars Of The University Of Oxford
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