Use of immobilized antagonists for enhancing growth factor...

Details Use of immobilized antagonists for enhancing growth factor... Use of immobilized antagonists for enhancing growth factor...

A - Human Necessities

61

L

A61L 27/54 (2006.01) A61L 31/16 (2006.01) C07K 17/00 (2006.01) C07K 14/475 (2006.01)

Patent

CA 2653866

Growth factors (GF) play an integral role in the repair and regeneration of tissues and exogenous GFs can be used to stimulate the repair of various tissues and organs. For exogenous growth factors to be effective in stimulating repair they must be retained at the site requiring repair, and be protected from inactivation, sequestration or degradation. To achieve this carriers are used. The current invention is based on the discovery that GF binding antagonists immobilized to carriers can enhance the efficacy of a growth factor containing bioimplant. This application provides a method for enhancing the efficacy of a bioimplant containing an exogenous growth factor by immobilizing an antagonist onto a carrier component of the bioimplant. This application further provide a bioimplant material and methods for manufacturing the bioimplant material.

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