Use of immobilized biotinylated receptor in test device, kit...

Details Use of immobilized biotinylated receptor in test device, kit... Use of immobilized biotinylated receptor in test device, kit...

G - Physics

01

N

167/44

G01N 33/566 (2006.01) G01N 33/545 (2006.01) G01N 33/76 (2006.01)

Patent

CA 1303495

-0- USE OF IMMOBILIZED BIOTINYLATED RECEPTOR IN TEST DEVICE, KIT AND METHOD FOR DETERMINING A LIGAND Abstract of the Disclosure A device useful for the determination of a ligand in an aqueous liquid comprises a water- insoluble substrate. Immobilized in at least one location on that substrate is a biotinylated receptor for the ligand. This receptor is in dried form and immobilized with one or more dried water-soluble acrylamide homo- or copolymer binder materials. When the immobilized receptor is contacted with an aqueous sample, the binder material is dissolved and the receptor is released for reaction with the ligand. The resulting reaction product is determined in a suitable manner. The device can be included in a kit having other components useful for ligand determina- tion. The device and method of its use are particu- larly useful for the determination of human chorionic gonadotropin (hCG) as an early indicator of pregnancy.

571854

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