Use of immunomodulating agents

Details Use of immunomodulating agents Use of immunomodulating agents

A - Human Necessities

61

K

A61K 31/7105 (2006.01) A61K 31/52 (2006.01) A61K 31/7076 (2006.01) A61K 31/711 (2006.01) A61K 31/7115 (2006.01) A61K 38/16 (2006.01) A61K 38/46 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 31/18 (2006.01) C12N 9/12 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2288215

It is described the use of several compounds capable of inhibiting cAMP-dependent protein kinase A (PKA) to produce a medicament increasing the T-cell proliferation in patients with immunosuppressive diseases. Inhibitors include cAMP analogues, ribozymes, antisense DNA and peptides binding to the anchoring region of PKA.

L'invention concerne l'utilisation de plusieurs composés capables d'inhiber la protéine kinase A (PKA) AMPc-dépendante afin de produire un médicament qui favorise la prolifération des lymphocytes T chez des patients atteints d'une maladie immunosuppressive. Parmi ces inhibiteurs, on trouve des analogues de l'AMPc, des ribozymes, de l'ADN antisens et des peptides se fixant sur la zone d'ancrage de la PKA.

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