A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2326692
The invention provides a method of treating diabetes in a subject, comprising administering to the diabetic subject an immunotoxin, thereby reducing the subject's T-cell population, and administering to the subject pancreatic islet cells from a donor. The immune tolerance inducing treatment regimen, used optionally with adjunct immunosuppressive agents, prevents pancreatic islet cell rejection while maintaining long term islet cell function following xenogeneic and allogeneic pancreatic islet cell transplantation. Thus, the methods of the present invention provide a means for treating diabetes, wherein the need for exogenous insulin or immunosuppressive agents is decreased or eliminated. Also provided is a method of inhibiting a rejection response of a transplant recipient, comprising administering an immunotoxin during the peritransplant period, thereby transiently reducing the number of T- cell lymphocytes and promoting long-term survival of the transplant.
L'invention porte sur une méthode de traitement du diabète consistant à administrer à un sujet diabétique une immunotoxine réduisant sa population de cellules T puis des cellules d'îlots de Langherans provenant d'un donneur. Suite à une transplantation de cellules xénogènes et allogènes d'îlots de Langherans, un régime induisant la tolérance immunitaire utilisé facultativement avec des agents immunosuppresseurs empêche le rejet desdites cellules tout en maintenant à long terme leur fonction. Cette méthode constitue donc un moyen de traitement du diabète réduisant ou éliminant les apports d'insuline exogène, ou d'immunosuppresseurs. L'invention porte également sur une méthode inhibant la réponse de rejet chez un transplanté consistant à lui administrer pendant la période de péritransplantation une immunotoxine réduisant transitoirement son nombre de lymphocytes T et favorisant la survie à long terme du transplant.
Neville David M.
Thomas Francis T.
Thomas Judith M.
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Gowling Lafleur Henderson Llp
The Uab Research Foundation
LandOfFree
Use of immunotoxins to induce immune tolerance to pancreatic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Use of immunotoxins to induce immune tolerance to pancreatic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Use of immunotoxins to induce immune tolerance to pancreatic... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1781772