C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/04 (2006.01) C12N 1/38 (2006.01) C12P 15/00 (2006.01) C12P 17/02 (2006.01)
Patent
CA 2556271
The invention is directed to a method for the production of taxanes by culturing suspension cells of Taxus sp.in a nutrient medium that comprises an indanoyl amino acid. The indanoyl amino acid may be added in batch mode or in a feed stream at any time of the culturing. In particular, synthetic compounds 6-Ethyl-indanoyl-isoleucine, 6-Bromoindanoyl isoleucine and 1-oxo-indane- carboxy-(L)-Isoleucine-methyl ester amide (1-OII) have been found to increase taxane production from Taxus cell cultures.
La présente invention concerne un procédé pour produire des taxanes par mise en culture de cellules en suspension de Taxus sp. dans un milieu nutritif qui comprend un acide aminé d'indanoyl. L'acide aminé d'indanoyl peut être ajouté par lots ou en continu à un instant quelconque de la culture. En particulier, il a été mis en évidence que des composés de synthèse amide d'ester de 1 -oxo-indane-carboxy-(L)-isoleucine-méthyl (1-OII), 6-éthyl-indanoyl-isoleucine et 6-bromoindanoyl isoleucine, augmentent la production de taxanes dans des cultures de cellules Taxus .
Alford Jennifer
Heckenmuller Harald
Roach Braden
Srinivasan Venkatesh
Mbm Intellectual Property Law Llp
Phyton Biotech Inc.
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