C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 31/18 (2006.01) C07D 471/14 (2006.01)
Patent
CA 2537752
The invention relates to indole-derived compounds and to the use of said compounds for the preparation of a medicament that can be used to treat diseases related to the process of splicing pre-messenger RNAs in the cell, such as Frasier syndrome, frontotemporal dementia linked to chromosome 17 (a form of Parkinson's disease), Leigh syndrome (a type of encephalopathy), atypical cystic fibrosis, certain neuropathologies including Alzheimer's disease linked to a mutation in the Tau protein, muscle atrophy which affects the SMN (Survival of Motor Neuron) gene, depression linked to a serotonin splicing impairment, and certain cancers in which the global splicing process is affected (e.g. breast cancer, colon cancer and certain lymphomas), as well as viral diseases such as AIDS.
Composés dérivés d'indole et utilisation desdits composés pour la préparation d'un médicament utile pour traiter des maladies liées au processus d'épissage des ARN pré-messagers dans la cellule, et notamment le syndrome de frasier, la démence fronto-temporale liée au chromosome 17 (une forme du Parkinson), le syndrome de Leigh (type d'encéphalopathie), la mucoviscidose atypique, certaines neuropathologies dont notamment l'Alzheimer lié à une mutation de la protéine Tau, l'amyotrophie qui touche le gène SMN (Survival of Motor Neuron), la dépression liée à un dérèglement de l'épissage de la sérotonine, et certains cancers dans lesquelles le processus global de l'épissage est affecté (notamment le cancer du sein, du colon et certains lymphomes), ainsi que les maladies virales telles que le SIDA.
Bisagni Emile
Grierson David
Jeanteur Philippe
Nguyen Chi Hung
Rivalle Christian
Centre National de La Recherche Scientifique (cnrs)
Institut Curie
Robic
Universite Montpellier II
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