Use of inhaled no as anti-inflammatory agent

A - Human Necessities – 61 – K

Patent

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Details

A61K 33/00 (2006.01) A61K 9/72 (2006.01) A61K 31/519 (2006.01) A61K 38/44 (2006.01)

Patent

CA 2309038

A method for lessening or preventing non-pulmonary ischemia-reperfusion injury or inflammation in a mammal by identifying a mammal which has ischemia-reperfusion or is at risk for developing ischemia- reperfusion in a non-pulmonary tissue; and causing the mammal to inhale a therapeutically effective amount of gaseous nitric oxide sufficient to diminish the ability of leukocytes or platelets to become activated in a manner that contributes to an inflammatory process at the site of the ischemia-reperfusion or inflammation in the non-pulmonary tissue, thereby lessening or preventing non-pulmonary ischemia- reperfusion injury in the mammal.

La présente invention concerne un procédé de réduction ou de prévention des lésions de reperfusions associées à l'ischémie ou inflammatoires dans un tissu non pulmonaire d'un mammifère. Le procédé consiste à identifier un mammifère soumis à des reperfusions associées à l'ischémie ou présentant un risque de développement de reperfusion associée à l'ischémie dans un tissu non pulmonaire. Ce procédé consiste également à amener le mammifère à inhaler une quantité thérapeutiquement efficace d'oxyde nitrique gazeux. Cette quantité est suffisante pour que soit réduite la capacité d'activation des leucocytes ou des plaquettes et participe à un processus inflammatoire au niveau du site des reperfusions associées à l'ischémie ou à une inflammation dans le tissu non pulmonaire. On empêche ainsi les lésions de reperfusions associées à l'ischémie chez un mammifère.

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