Use of inhibitors of fatty acid synthesis for treating cancer

Details Use of inhibitors of fatty acid synthesis for treating cancer Use of inhibitors of fatty acid synthesis for treating cancer

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/00 (2006.01) A61K 31/15 (2006.01) A61K 31/20 (2006.01) A61K 31/23 (2006.01) A61K 31/335 (2006.01) A61K 31/336 (2006.01) A61K 31/34 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12N 9/10 (2006.01) C12Q 1/48 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2140866

Fatty acid synthase (FAS) is overexpressed in carcinomas with poor prognosis, but little FAS expression is identified in normal tissues. Inhibition of fatty acid synthesis is selectively toxic to carcinoma cells, while normal cells with low FAS activity are resistant. This invention provides a method of treating cancer patients where fatty acid synthesis by cells of the patient's tumor is inhibited with resultant interruption of the disease process.

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