Use of inhibitors of plac8 activity for the modulation of...

Details Use of inhibitors of plac8 activity for the modulation of... Use of inhibitors of plac8 activity for the modulation of...

C - Chemistry, Metallurgy

07

K

C07K 14/47 (2006.01) A61K 38/57 (2006.01)

Patent

CA 2742770

The present invention concerns Plac8, a new target involved in adipogenesis modulation. Using a siRNA ap-proach, the inventors demonstrated that decrease in Plac8 activity in preadipocytes and adipose tissue induces a decrease in adipo-genesis. Thus, the present invention relates to modulators of Plac8 activity as well as screening test for identification of modula-tors of the activity of this target, and their use, especially in pharmaceutical composition, to modulate adipogenesis and thus treat obesity and related disorders.

La présente invention porte sur Plac8, une nouvelle cible impliquée dans la modulation de l'adipogenèse. A l'aide d'une approche ARNsi, les inventeurs ont démontré qu'une diminution de l'activité Plac8 dans des préadipocytes et un tissu adipeux induit une diminution de l'adipogenèse. Ainsi, la présente invention porte sur des modulateurs de l'activité Plac8 ainsi que sur un essai de criblage pour une identification de modulateurs de l'activité de cette cible, et sur leur utilisation, notamment dans une composition pharmaceutique, pour moduler l'adipogenèse et ainsi traiter l'obésité et les troubles apparentés.

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