Use of inhibitors of prenyltransferases for inhibiting...

Details Use of inhibitors of prenyltransferases for inhibiting... Use of inhibitors of prenyltransferases for inhibiting...

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61P 31/10 (2006.01) C07C 323/25 (2006.01) C07C 323/42 (2006.01) C07C 323/59 (2006.01) C07D 401/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01) C07K 5/02 (2006.01) C07K 5/065 (2006.01) C07K 5/103 (2006.01)

Patent

CA 2335381

The present invention relates to compositions and methods for inhibiting fungal growth. In particular, the present invention relates to methods for use as anti-fungal agents of inhibitors, and compositions thereof, of fungal prenyltransferases, e.g., FPTase and GGPTase. The inhibitors of fungal prenyltransferases may be peptides, peptidomimetics, or non-peptides.

L'invention concerne des compositions et des procédés permettant d'inhiber la prolifération fongique. En particulier, l'invention concerne des procédés relatifs à l'utilisation, comme agents antifongiques, d'inhibiteurs et de compositions à base d'inhibiteurs de prényltransférase fongique (par exemple, FPTase et GGPTase). Les inhibiteurs de ce type de prényltransférase peuvent être des peptides, des peptidomimétiques ou des éléments autres que les peptides.

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