A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/17 (2006.01) A61K 31/00 (2006.01) A61K 31/045 (2006.01) A61K 31/13 (2006.01) A61K 31/335 (2006.01) A61K 31/336 (2006.01) A61L 27/54 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2473489
The present invention provides methods of slowing or inhibiting vascular smooth muscle (VSM) cell proliferation to slow the development or recurrence of atherosclerosis by contacting VSM cells with soluble epoxide hydrolase (sEH) inhibitors. Further, the methods of the invention can be used to slow or to inhibit vascular restenosis after angioplasty and the stenosis of vascular stents. Further, the methods of the invention can be used to slow or to inhibit the stenosis of hemodialysis grafts and other natural and synthetic vascular grafts. The invention further provides the use of sEH inhibitors for the manufacture of medicaments to slow or inhibit VSM cell proliferation.
L'invention concerne des procédés permettant de ralentir ou d'inhiber la prolifération des cellules vasculaires des muscles lisses (VSM) afin de limiter l'évolution ou la récurrence de l'athérosclérose, ce qui consiste à mettre en contact ces cellules vasculaires avec des inhibiteurs d'époxyde hydrolase soluble (sEH). On peut également mettre en application ces procédés pour ralentir ou inhiber la resténose vasculaire après une angioplastie ou la sténose des extenseurs vasculaires. On peut, de plus, mettre en application ces procédés afin de ralentir ou d'inhiber la sténose des greffes d'hémodialyse ou d'autres greffes vasculaires naturelles ou synthétiques. Elle concerne également l'utilisation de ces inhibiteurs de sEH afin de préparer des médicaments servant à ralentir ou à inhiber la prolifération des cellules vasculaires des muscles lisses.
Hammock Bruce D.
Weiss Robert H.
Fetherstonhaugh & Co.
The Regents Of The University Of California
LandOfFree
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